Day 1 :
Keynote Forum
Sergey Suchkov
Institute for Global Health of MGUPP and A.I. Evdokimov MGMSU, Russia
Keynote: Personalized and Precision Medicine (PPM) as a unique healthcare model to be set up via biodesign, bio and chemical engineering, translational applications and upgraded business modeling to secure the human healthcare and biosafety
Biography:
Sergey Suchkov was born in the City of Astrakhan, Russia, in a family of dynasty medical doctors. In 1980, graduated from Astrakhan State Medical University and was awarded with MD. In 1985, Suchkov maintained his PhD as a PhD student of the I.M. Sechenov Moscow Medical Academy and Institute of Medical Enzymology. In 2001, Suchkov maintained his Doctor Degree at the National Institute of Immunology, Russia. From 1989 through 1995, Dr. Suchkov was being a Head of the Lab of Clinical Immunology, Helmholtz Eye Research Institute in Moscow. From 1995 through 2004 - a Chair of the Dept for Clinical Immunology, Moscow Clinical Research Institute (MONIKI). In 1993-1996, Dr. Suchkov was a Secretary-in-Chief of the Editorial Board, Biomedical Science, an international journal published jointly by the USSR Academy of Sciences and the Royal Society of Chemistry, UK.
Abstract:
Traditionally a disease has been defined by its clinical presentation and observable characteristics, not by the underlying molecular mechanisms, pathways and systems biology-related processes specific to a particular patient (ignoring persons-at-risk). A new systems approach to subclinical and/or diseased states and wellness resulted in a new trend in the healthcare services, namely, Personalized and Precision Medicine (PPM).
To achieve the implementation of PPM concept, it is necessary to create a fundamentally new strategy based upon the biomarkers and targets to have a unique impact for the implementation of PPM model into the daily clinical practice and pharma. In this sense, despite breakthroughs in research that have led to an increased understanding of PPM-based human disease, the translation of discoveries into therapies for patients has not kept pace with medical need. It would be extremely useful to integrate data harvesting from different databanks for applications such as prediction and personalization of further treatment to thus provide more tailored measures for the patients and persons-at-risk resulting in improved outcomes and more cost effective use of the latest health care resources including diagnostic (companion ones), preventive and therapeutic (targeted molecular and cellular) etc.
Translational researchers, bio-designers and manufacturers are beginning to realize the promise of PPM, translating to direct benefit to patients or persons-at-risk. For instance, companion diagnostics tools and targeted therapies and biomarkers represent important stakes for the pharma, in terms of market access, of return on investment and of image among the prescribers. At the same time, they probably represent only the generation of products resulting translational research and applications. So, developing medicines and predictive diagnostic tools requires changes to traditional clinical trial designs, as well as the use of innovative (adaptive) testing procedures that result in new types of data. Making the best use of those innovations and being ready to demonstrate results for regulatory bodies requires specialized knowledge that many clinical development teams don’t have. The areas where companies are most likely to encounter challenges, are data analysis and workforce expertise, biomarker and diagnostic test development, and cultural awareness. Navigating those complexities and ever-evolving technologies will pass regulatory muster and provide sufficient data for a successful launch of PPM, is a huge task. So, partnering and forming strategic alliances between researchers, bio-designers, clinicians, business, regulatory bodies and government can help ensure an optimal development program that leverages the Academia and industry experience and FDA’s new and evolving toolkit to speed our way to getting new tools into the innovative markets.
Healthcare is undergoing a transformation, and it is imperative to leverage new technologies to support the advent of PPM. This is the reason for developing global scientific, clinical, social, and educational projects in the area of PPM and TraMed to elicit the content of the new trend. The latter would provide a unique platform for dialogue and collaboration among thought leaders and stakeholders in government, academia, industry, foundations, and disease and patient advocacy with an interest in improving the system of healthcare delivery on one hand and drug discovery, development, and translation, on the other one, whilst educating the policy community about issues where biomedical science and policy intersect.
- Nanotechnology
Location: Webinar
- Nano Materials Synthesis and Characterisation | Nanoscience and Technology | Nano Computational Modelling | Materials Science and Engineering | Pharamaceutical Chemistry | Anti-Infective Agents in Medicinal Chemistry | Neuroscience and Neurochemistry | Pharmaceutical Analysis
Location: Webinar
Session Introduction
Marvit Osman Widdatallah Omer
University of Medical Sciences and Technology, Sudan
Title: Silver and gold nanoparticles using green method of synthesis and ealuation of their antibacterial activity
Biography:
Marvit Osman Widdatallah Omer MSc in PHARMACOLOGY (Pharmacokinetic Specialization) from University of medical sciences and technology (UMST) at 2018. Upheld an outstanding record of academic combined with practical experiences. I completed a bachelor of pharmacy at UMST at 2016, and now am a lecturer at the department of pharmacology and also member in the university research group, interested in researching especially new fields of Nanotechnology and Molecular genetics, beside all of those I got distinction in higher diploma in developmental studies where I believe we need to be in contact for the socities problems to get our researches in the way of helping and make touch. Last year I was completing the registration to Phd programe and now am working through it in pharmacogenetics specializations to identify the relation of different ethnic groups genetically to their impact on the drugs respone. Seven published papers were published throughout my year of experiances in area of pharmacological response of different chemical components either plants exract or the synthetic nanoparticles, nowadays am working in two different review papers beside molecular base research on the mechanism of bacterial resistances toward the antibiotics among a category of Sudanese population.
Abstract:
Synthesis of silver nanoparticles and Gold nanoparticles using seeds of Nigella sativa and black tea as a capping agents were evaluated in those studies. Different concentrations of the aqueous extract of plants exrtract with silver nitrate solution and Gold salt solutions were exposed to sunlight; as a force for acceleration of the formulation. Then the nanoparticles were characterized by UV-Vis, scanning electron microscope (SEM) and X-ray diffraction (XRD) techniques. Antibacterial activities of the nanoparticles were investigated against Staphylococcus aureus and Escherichia coli as represent the most common types of pathogenic bacteria by the disc diffusion method. The characterization of nanoparticles were detected by the change in color to yellow-brown in silver NPs and pink-purple in Gold NPs which indicated the formulation of nanoparticles and another techniques according to the different in the capping agents in the plants extracts. Different shapes within range of nanoscale were detected using SEM and XRD techniques. The finding suggests that nanoparticles may be effectively used as antibacterial agent as being a future for many fields espically in area of bacterial resistance toward antibiotics.
Dhritiman Chakraborty
Amity University, India
Title: Modelling effects of disorder on thermal conductivity in highly disordered nanostructures
Biography:
Over the span of his academic tenure Dr. Dhritiman Chakraborty has had the opportunity of interaction, stay, study, research and teaching at educational institutes spread across six different countries (UK, Russia, Indonesia, Kazakhstan, India and Japan) and different universities. After completing his Bachelors in Physics from St. Stephen’s college in Delhi University, he went on to the study and research in the field of Nanotechnology, collaborating with various institutes, culminating in his PhD from the University of Warwick, UK. This abstract presents an excerpt of his research, done at the University of Warwick, with additions from his collaborators at Amity University in India.
Abstract:
Nanostructuring of thermoelectric materials is a method with great potential for improved and novel thermoelectric materials with ultra-low thermal conductivities and improved power factors, thereby enhanced thermoelectric efficiencies. Nanostructuring introduces scattering of phonons of various wavelengths and hence reduces phonon transport throughout the spectrum–yielding ultra-low thermal conductivities. Introducing disorder at the nanoscale reduces thermal conductivity even further. However, there are very few models that accurately determine how disorder reduces thermal conductivity in nanostructured materials.
In this work, we provide simplified models that accurately describe the effects of disorder and porosity at the nanoscale by solving the Boltzmann transport equation for phonons using the Monte Carlo method in Si-based nanostructures with a large degree of disorder. We examine nanostructures with nanocrystalline grain structures in addition to nanopores, both in an ordered and highly randomized fashion. Such materials have demonstrated experimentally thermal conductivities even below the amorphous limit. We extract analytical models that capture quantitatively the thermal conductivity in nanostructures that include a combination of nanograins and nanopores, in disordered nanostructures. Finally, we compare our models with predictions by Mattheissen’s rule and find good agreement.
Biography:
Sudip Chatterjee is working as a Professor of Applied Physics at Swami Vivekananda University, India and engaged in the active research in the field of Nanotechnology, Nanocomposites and characterization of Bionanoparticles. He has published more than 30 Research articles in internationally reputed journals and has been invited by different organizations for giving Lectures on his research area. Before joining at Regent Education and Research Foundation, he has also worked as an Associate Professor at IFHE University, Hyderabad, India and as an Assistant Professor at Sikkim Manipal Institute of Technology
Abstract:
The objective of this paper is to provide a mathematical model to construct a barrier that may be useful to prevent the penetration of different viruses (Eg. SARS-COV-2) as well as charged aerosols through the concept of electrostatic charge negotiation. (Fusion for the opposite types of charges and repulsion for the similar types of charges). Reviewing the works of different authors, regarding charges, surface charge densities (σ), charge mobility (μ) and electrostatic potentials of different aerosols under varied experimental conditions, a similar intensive study has also been carried out to investigate the electron donating and accepting (hole donating) properties of the spike proteins (S-proteins) of different RNA and DNA viruses, including SARS-COV-2. Based upon the above transport properties of electrons of different particles having different dimensions, a mathematical model has been established to find out the penetration potential of those particles under different electrostatic fields. An intensive study have been carried out to find out the generation of electrostatic charges due to the surface emission of electrons (SEE), when a conducting material like silk, nylon or wool makes a friction with the Gr IV elements like
Germanium or Silicon, it creates an opposite layer of charges in the outer conducting surface and the inner semiconducting surface separated by a dielectric material. This opposite charge barriers may be considered as Inversion layers (IL). The electrostatic charges accumulated in the layers between the Gr IV Ge is sufficient enough to either fuse or repel the charges of the spike proteins of the RNA, DNA viruses including SARS-Cov-2 (RNA virus) or the aerosols.
Key words: SEE, Transport properties, Inversion Layer, Surface charge density, SARS-Cov-2.
Andrey Belousov
Laboratory of Applied Nanotechnology of Belousov, Ukraine
Title: Influence of physical factors caused by magnetite nanoparticles (MCS-B) on different groups of microorganisms
Biography:
Andrey Nikolaevych Belousov is DM, Professor. Author a new medicine products – nanotechnology preparations based on magnetite nanoparticles (Fe3O4) of the size 6-12 nm: the preoral form - Micromage-B (officially registration in Ukraine); Magnet-controlled sorbent brand of MCS-B (officially registration in Ukraine and was allowed for medical practice); NanoBiocorrector for intravenous application – ICNB (intracorporal nanosorbent). Author a new program (PHUAS) for estimation degree the severity of the patient. The published more 230 scientific works. At now Andrey Belousov - the Head of Laboratory Applied Nanotechnologies in Ukraine, Professor of Department Anesthesiology, Intensive Care, Transfusiology and Hematology Kharkov Medical Academy of Postgraduate Education.
Abstract:
The influence of basic physical factors caused by magnetite nanoparticles (constant magnetic field and sorption) on microorganisms by examining the reactions of the intensity of Free Radical Lipid Peroxidation (FRLP) and bacteriostatic action was studied. It was well established that the magnetite nanoparticles (MCS-B) caused unequal reaction in intensity of FRLP on different groups of microorganisms. It was determined that the most significant factor that influenced on the ultimate indicator of the intensity of luminescence on Candida albicans, Escherichia coli and Pseudomonas aeruginosa was constant magnetic field which induced by nanoparticles. On the contrary, sorption was the most significant factor on Staphylococcus aureus. It was found that the rate of consumption of free radicals lipid reduced reliably on all microorganisms after their processing by magnetite nanoparticles (MCS-B). The results of microbiological studies of Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus showed that bacteriostatic effect was detected after exposure by magnetite nanoparticles. Visually, it was detected by decreasing the number of colonies on the nutritious medium in comparison with the control (Figure 1). It was revealed an interesting fact that saline NaCl, which had previously been processed by magnetite nanoparticles also significantly, had a marked bacteriostatic effect on the studied microorganisms. This effect could be explained by mechanism of change the polarization structure water of microorganisms by magnetite nanoparticles (MCS-B). It was discovered that degree of expression of bacteriostatic action which induced by magnetite nanoparticles had correlation with marks of reactions intensity of FRLP. Maximum bacteriostatic effect on Staphylococcus aureus was expressed in second variant application of magnetite nanoparticles where mechanism of sorption was more significant than action of the magnetic field. On the contrary, maximum bacteriostatic effect on Escherichia coli and Klebsiella pneumoniae was revealed in third variant, where time exposition of contact with microorganism’s nanoparticles and, consequently, action of a constant magnetic field was determinative.